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Article

Genetic Variation between Dengue Virus Type 4 Strains Impacts Human Antibody Binding and Neutralization.

Cell reports - 30 Oct 2018

Gallichotte Emily N, Baric Thomas J, Nivarthi Usha, Delacruz Matthew J, Graham Rachel, Widman Douglas G, Yount Boyd L, Durbin Anna P, Whitehead Stephen S, de Silva Aravinda M, Baric Ralph S

Abstract excerpt

There are four distinct DENV serotypes, and within DENV4, there are five distinct genotypes. The impact of genotypic diversity is not known, nor is it clear whether infection with one DENV4 genotype results in protective immunity against the other genotypes. To measure the impact of DENV4 genetic diversity, we generated an isogenic panel of viruses containing the envelope protein from the different genotypes. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30380413
DOI: 10.1016/j.celrep.2018.10.006
PMCID: PMC6226424

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