Article
Virus-like particle secretion and genotype-dependent immunogenicity of dengue virus serotype 2 DNA vaccine.
Journal of virology - 1 Sept 2014
Galula Jedhan U, Shen Wen-Fan, Chuang Shih-Te, Chang Gwong-Jen J, Chao Day-Yu
Abstract excerpt
UNLABELLED: Dengue virus (DENV), composed of four distinct serotypes, is the most important and rapidly emerging arthropod-borne pathogen and imposes substantial economic and public health burdens. We constructed candidate vaccines containing the DNA of five of the genotypes of dengue virus serotype 2 (DENV-2) and evaluated the immunogenicity, the neutralizing (Nt) activity of the elicited antibodies, and the...
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