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Article

Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy.

eLife - 5 Sept 2017

Rabaa Maia A, Girerd-Chambaz Yves, Duong Thi Hue Kien, Vu Tuan Trung, Wills Bridget, Bonaparte Matthew, van der Vliet Diane, Langevin Edith, Cortes Margarita, Zambrano Betzana, Dunod Corinne, Wartel-Tram Anh, Jackson Nicholas, Simmons Cameron P

Abstract excerpt

This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity...

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Identifiers

PMID: 28871961
DOI: 10.7554/eLife.24196
PMCID: PMC5584992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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