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Article

Dengue Virus Serotype 1 Conformational Dynamics Confers Virus Strain-Dependent Patterns of Neutralization by Polyclonal Sera.

Journal of virology - 9 Nov 2021

VanBlargan Laura A, Milutinovic Pavle S, Goo Leslie, DeMaso Christina R, Durbin Anna P, Whitehead Stephen S, Pierson Theodore C, Dowd Kimberly A

Abstract excerpt

Dengue virus cocirculates globally as four serotypes (DENV1 to -4) that vary up to 40% at the amino acid level. Viral strains within a serotype further cluster into multiple genotypes. Eliciting a protective tetravalent neutralizing antibody response is a major goal of vaccine design, and efforts to characterize epitopes targeted by polyclonal mixtures of antibodies are ongoing. Previously, we identified two E...

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Identifiers

PMID: 34549976
DOI: 10.1128/JVI.00956-21
PMCID: PMC8577358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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