Article
Dengue antigenic relationships predict evolutionary dynamics
2018-10-02
Abstract excerpt
Dengue virus (DENV) exists as four genetically distinct serotypes, each of which is historically assumed to be antigenically uniform. However, recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact remain unclear. Here, we construct a sequence-based model to directly map antigenic change to underlying genetic divergence. We identify 49 specific substi...
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Identifiers and source
- Literature Corpus work
- b0487287-bd67-5098-a6b5-1234bf0da0c4
- DOI
- 10.1101/432054