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Cell-Specific Transposable Element Gene Expression Analysis Identifies Associations with Systemic Lupus Erythematosus Phenotypes

2023-11-28

Abstract excerpt

There is an established yet unexplained link between interferon (IFN) and systemic lupus erythematosus (SLE). The expression of sequences derived from transposable elements (TEs) may contribute to production of type I IFNs and generation of autoantibodies. We profiled cell-sorted RNA-seq data (CD4+ T cells, CD14+ monocytes, CD19+ B cells, and NK cells) from PBMCs of 120 SLE patients and quantified TE expression id...

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Literature Corpus work
2f761cfc-4ac8-56c0-a35e-c89e8e286355
DOI
10.1101/2023.11.27.567477
Open publication

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Cell-Specific Transposable Element Gene Expression Analysis Identifies Associations with Systemic Lupus Erythematosus PhenotypesDOI 10.1101/2023.11.27.567477
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