Article
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis.
Cardiovascular research - 1 Mar 2019
Herraiz-Martínez Adela, Llach Anna, Tarifa Carmen, Gandía Jorge, Jiménez-Sabado Verónica, Lozano-Velasco Estefanía, Serra Selma A, Vallmitjana Alexander, Vázquez Ruiz de Castroviejo Eduardo, Benítez Raúl, Aranega Amelia, Muñoz-Guijosa Christian, Franco Diego, Cinca Juan, Hove-Madsen Leif
Abstract excerpt
AIMS: Single nucleotide polymorphisms on chromosome 4q25 have been associated with risk of atrial fibrillation (AF) but the exiguous knowledge of the mechanistic links between these risk variants and underlying electrophysiological alterations hampers their clinical utility. Here, we tested the hypothesis that 4q25 risk variants cause alterations in the intracellular calcium homoeostasis that predispose to...
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