Article
Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function.
Cardiovascular research - 14 Aug 2026
Jiménez-Sábado Verónica, Tarifa Carmen, Vad Oliver B, Casabella-Ramón Sergi, Manzano-Reche Gabriel, Lozano-Velasco Estefanía, Aceituno Cristina, Caño-Carrillo Sheila, Domínguez Jorge N, Paludan-Müller Christian, Andreasen Laura, Montiel José, Guerra Jose M, Franco Diego, Svendsen Jesper H, Rodriguez-Font Enrique, Ginel Antonino, Olesen Morten S, Hove-Madsen Leif
Abstract excerpt
AIMS: Single-nucleotide polymorphisms (SNPs) from distinct linkage blocks in the chromosomal region 4q25 (rs1448818, rs2200733, and rs10033464) are associated with increased risk of atrial fibrillation (AF), but their impact on cardiomyocyte and atrial function remains elusive. Here, we tested the hypothesis that these SNPs have differential effects on calcium homeostasis that may afford SNP-specific targets and...
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