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Article

Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation.

ACS chemical biology - 16 Oct 2020

Cogan Dillon P, Ly Joseph, Nair Satish K

Abstract excerpt

While several bioactive natural products that contain tetramate or pyridone heterocycles have been described, information on the enzymology underpinning these functionalities has been limited. Here we biochemically characterize an off-loading Dieckmann cyclase, NcmC, that installs the tetramate headgroup in nocamycin, a hybrid polyketide/nonribosomal peptide natural product. Crystal structures of the enzyme (1.6...

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Actinobacteria
Carbon-Carbon Ligases
Computational Biology
Cyclization
Models, Chemical

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Molecular Docking Simulation

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PMID: 33017142
DOI: 10.1021/acschembio.0c00579
PMCID: PMC13085894

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