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Article

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.

Chembiochem : a European journal of chemical biology - 24 Jan 2014

Baer Philipp, Rabe Patrick, Citron Christian A, de Oliveira Mann Carina C, Kaufmann Norman, Groll Michael, Dickschat Jeroen S

Abstract excerpt

The biosynthesis of terpenes is catalysed by class I and II terpene cyclases. Here we present structural data from a class I hedycaryol synthase in complex with nerolidol, serving as a surrogate for the reaction intermediate nerolidyl diphosphate. This prefolded ligand allows mapping of the active site and hence the identification of a key carbonyl oxygen of Val179, a highly conserved helix break (G1/2) and its...

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Crystallography, X-Ray
Hydrogen-Ion Concentration
Ligases
Models, Molecular
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Secondary

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PMID: 24399794
DOI: 10.1002/cbic.201300708

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