Impact of radiotherapy site, modality, and dose on subsequent clonal hematopoiesis

Abstract excerpt

Clonal hematopoiesis (CH) is the clonal expansion of hematopoietic stem and progenitor cells harboring somatic mutations, and carries an increased risk of myeloid neoplasia and all-cause mortality.1 Exposure to cancer therapies, including radiotherapy (RT), can select and promote the expansion of CH clones, particularly those carrying mutations in DNA damage response (DDR) genes, including TP53. 2 Notably,...

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