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Article

Mechanisms of M2 Macrophage-Derived Exosomal Long Non-coding RNA PVT1 in Regulating Th17 Cell Response in Experimental Autoimmune Encephalomyelitisa.

Frontiers in immunology - 1 Jan 2020

Wu Lei, Xia Jinjin, Li Donghui, Kang Ying, Fang Wei, Huang Peng

Abstract excerpt

Long non-coding RNA (lncRNA) is pivotal for multiple sclerosis (MS), but the potential mechanism of lncRNA PVT1 in MS animal model, experimental autoimmune encephalomyelitis (EAE) still remains unclear. In this study, macrophages were firstly isolated and induced to polarize into M2 macrophages. M2 macrophage-derived exosomes (M2-exos) were extracted and identified, and EAE mouse model was established and treated...

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Share to Encephalomyelitis, Autoimmune, Experimental
Share to Exosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

Share to Macrophages, Peritoneal

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Share to STAT3 Transcription Factor

Share to Suppressor of Cytokine Signaling Proteins

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Source

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Identifiers

PMID: 33013847
DOI: 10.3389/fimmu.2020.01934
PMCID: PMC7500097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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