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Article

miR-141 and miR-200a, Revelation of New Possible Players in Modulation of Th17/Treg Differentiation and Pathogenesis of Multiple Sclerosis

4 May 2015

Abstract excerpt

BACKGROUND: One of the main issues in pathogenesis of MS is Th17/Treg imbalance. There are growing interests in nominating miRNAs involved in Th17 cell differentiation, suggesting them as new therapeutic agents that may reduce progression of different autoimmune diseases specially MS. OBJECTIVES: We assessed transcript levels of miR-141 and miR-200a in MS patients, during relapsing and remitting phases. We also...

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PMID: 25938517
DOI: 10.1371/journal.pone.0124555

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