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Article

Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.

Journal of cellular and molecular medicine - 1 Nov 2020

Wang Yongqi, Han Biao, Wang Yingbin, Wang Chunai, Zhang Hong, Xue Jianjun, Wang Xiaoqing, Niu Tingting, Niu Zhen, Chen Yuhe

Abstract excerpt

The effects of mesenchymal stem cells (MSCs) on different types of diseases are controversial, and the inner mechanisms remain unknown, which retards the utilization of MSCs in disease therapy. In this study, we aimed to elucidate the mechanisms of MSCs-extracellular vesicles (EVs) carrying transforming growth factor-beta 1 (TGF-β1) in M2 polarization in mouse macrophages via the microRNA-132 (miR-132)/E3...

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Identifiers

PMID: 32965772
DOI: 10.1111/jcmm.15860
PMCID: PMC7686990

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