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Article

The bacterial condensin MukB compacts DNA by sequestering supercoils and stabilizing topologically isolated loops.

The Journal of biological chemistry - 13 Oct 2017

Kumar Rupesh, Grosbart Małgorzata, Nurse Pearl, Bahng Soon, Wyman Claire L, Marians Kenneth J

Abstract excerpt

MukB is a structural maintenance of chromosome-like protein required for DNA condensation. The complete condensin is a large tripartite complex of MukB, the kleisin, MukF, and an accessory protein, MukE. As found previously, MukB DNA condensation is a stepwise process. We have defined these steps topologically. They proceed first via the formation of negative supercoils that are sequestered by the protein...

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Identifiers

PMID: 28842486
DOI: 10.1074/jbc.M117.803312
PMCID: PMC5641887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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