Article
Macroscopic somatic clonal expansion in morphologically normal human urothelium.
Science (New York, N.Y.) - 2 Oct 2020
Li Ruoyan, Du Yiqing, Chen Zhanghua, Xu Deshu, Lin Tianxin, Jin Shanzhao, Wang Gongwei, Liu Ziyang, Lu Min, Chen Xu, Xu Tao, Bai Fan
Abstract excerpt
Knowledge of somatic mutation accumulation in normal cells, which is essential for understanding cancer development and evolution, remains largely lacking. In this study, we investigated somatic clonal events in morphologically normal human urothelium (MNU; epithelium lining the bladder and ureter) and identified macroscopic clonal expansions. Aristolochic acid (AA), a natural herb-derived compound, was a major...
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