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Article

Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome

29 Sept 2020

Abstract excerpt

Objective The purpose of this study was to infer causal relationships between 22 previously reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid (CSF) levels of amyloid‐β (Aβ 42 ), tau, and ptau 181 , and the neuropathological burden of neuritic plaques, neurofibrillary tangles (NFTs), and...

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PMID: 32996171
DOI: 10.1002/ana.25918

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