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Article

PAI-1, the Plasminogen System, and Skeletal Muscle

25 Sept 2020

Abstract excerpt

The plasminogen system is a critical proteolytic system responsible for the remodeling of the extracellular matrix (ECM). The master regulator of the plasminogen system, plasminogen activator inhibitor-1 (PAI-1), has been implicated for its role in exacerbating various disease states not only through the accumulation of ECM (i.e., fibrosis) but also its role in altering cell fate/behaviour. Examination of PAI-1...

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PMID: 32993026
DOI: 10.3390/ijms21197066

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