Plasmin Prevents Dystrophic Calcification After Muscle Injury.

doi:10.1002/jbmr.2973

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Article

Plasmin Prevents Dystrophic Calcification After Muscle Injury.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2017

Mignemi Nicholas A, Yuasa Masato, Baker Courtney E, Moore Stephanie N, Ihejirika Rivka C, Oelsner William K, Wallace Christopher S, Yoshii Toshitaka, Okawa Atsushi, Revenko Alexey S, MacLeod A Robert, Bhattacharjee Gourab, Barnett Joey V, Schwartz Herbert S, Degen Jay L, Flick Matthew J, Cates Justin M, Schoenecker Jonathan G

Abstract excerpt

Extensive or persistent calcium phosphate deposition within soft tissues after severe traumatic injury or major orthopedic surgery can result in pain and loss of joint function. The pathophysiology of soft tissue calcification, including dystrophic calcification and heterotopic ossification (HO), is poorly understood; consequently, current treatments are suboptimal. Here, we show that plasmin protease activity...

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PMID: 27530373
DOI: 10.1002/jbmr.2973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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