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Article

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.

Nucleic acids research - 16 Dec 2021

Batenburg Nicole L, Mersaoui Sofiane Y, Walker John R, Coulombe Yan, Hammond-Martel Ian, Wurtele Hugo, Masson Jean-Yves, Zhu Xu-Dong

Abstract excerpt

Cockayne syndrome group B (CSB) protein has been implicated in the repair of a variety of DNA lesions that induce replication stress. However, little is known about its role at stalled replication forks. Here, we report that CSB is recruited to stalled forks in a manner dependent upon its T1031 phosphorylation by CDK. While dispensable for MRE11 association with stalled forks in wild-type cells, CSB is required...

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Source

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Identifiers

PMID: 34871413
DOI: 10.1093/nar/gkab1173
PMCID: PMC8682776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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