Article
CSB is a component of RNA pol I transcription.
Molecular cell - 1 Oct 2002
Bradsher John, Auriol Jerome, Proietti de Santis Luca, Iben Sebastian, Vonesch Jean Luc, Grummt Ingrid, Egly Jean Marc
Abstract excerpt
Mutation in the CSB gene results in the human Cockayne's syndrome (CS). Here, we provide evidence that CSB is found not only in the nucleoplasm but also in the nucleolus within a complex (CSB IP/150) that contains RNA pol I, TFIIH, and XPG and promotes efficient rRNA synthesis. CSB is active in in vitro RNA pol I transcription and restores rRNA synthesis when transfected in CSB-deficient cells. We also show that...
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