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Article

The Winged Helix Domain of CSB Regulates RNAPII Occupancy at Promoter Proximal Pause Sites.

International journal of molecular sciences - 25 Mar 2021

Batenburg Nicole L, Cui Shixin, Walker John R, Schellhorn Herb E, Zhu Xu-Dong

Abstract excerpt

Cockayne syndrome group B protein (CSB), a member of the SWI/SNF superfamily, resides in an elongating RNA polymerase II (RNAPII) complex and regulates transcription elongation. CSB contains a C-terminal winged helix domain (WHD) that binds to ubiquitin and plays an important role in DNA repair. However, little is known about the role of the CSB-WHD in transcription regulation. Here, we report that CSB is...

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Identifiers

PMID: 33806087
DOI: 10.3390/ijms22073379
PMCID: PMC8037043

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