Article
Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.
Journal of translational medicine - 8 Jun 2018
Juárez-Flores Diana Luz, González-Casacuberta Ingrid, Ezquerra Mario, Bañó María, Carmona-Pontaque Francesc, Catalán-García Marc, Guitart-Mampel Mariona, Rivero Juan José, Tobias Ester, Milisenda Jose Cesar, Tolosa Eduard, Marti Maria Jose, Fernández-Santiago Ruben, Cardellach Francesc, Morén Constanza, Garrabou Glòria
Abstract excerpt
BACKGROUND: Mutations in leucine rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD). Mitochondrial and autophagic dysfunction has been described as etiologic factors in different experimental models of PD. We aimed to study the role of mitochondria and autophagy in LRRK2 G2019S -mutation, and its relationship with the presence of PD-symptoms. METHODS: Fibroblasts from six...
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