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Article

Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide.

Biochimica et biophysica acta. Molecular and cell biology of lipids - 1 Jan 2021

Honda Takuya, Motoyoshi Kaisei, Kasahara Junya, Yamagata Kazuyuki, Takahashi Hiromasa, Nakamura Hiroyuki, Murayama Toshihiko

Abstract excerpt

Sphingolipids represent a family of cellular lipid-molecules that regulate physiological and pathophysiological processes. Glucosylceramide (GlcCer), the simplest glycosphingolipid (GSL), is synthesized from ceramide and UDP-glucose by GlcCer synthase (GCS). Both GlcCer (and resulting GSLs) and ceramide regulate various cellular functions including cell death and multiple drug resistance. Src family tyrosine...

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PMID: 32980536
DOI: 10.1016/j.bbalip.2020.158817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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