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Article

Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.

Molecular & cellular proteomics : MCP - 1 Aug 2012

Ferrando Isabel Martinez, Chaerkady Raghothama, Zhong Jun, Molina Henrik, Jacob Harrys K C, Herbst-Robinson Katie, Dancy Beverley M, Katju Vikram, Bose Ron, Zhang Jin, Pandey Akhilesh, Cole Philip A

Abstract excerpt

The cellular proto-oncogene c-Src is a nonreceptor tyrosine kinase involved in cell growth and cytoskeletal regulation. Despite being dysregulated in a variety of human cancers, its precise functions are not fully understood. Identification of the substrates of c-Src remains a major challenge, because there is no simple way to directly stimulate its activity. Here we combine the chemical rescue of mutant c-Src...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22499769
DOI: 10.1074/mcp.M111.015750
PMCID: PMC3412967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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