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Article

Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells

6 Feb 2007

Abstract excerpt

The role of dihydroceramide desaturase as a key enzyme in the de novo pathway of ceramide generation was investigated in human neuroblastoma cells (SMS-KCNR). A novel assay using water-soluble analogs of dihydroceramide, dihydroceramidoids (D-erythro-dhCCPS analogs), was used to measure desaturase activity in situ. Conversion of D-erythro-2-N-[12'-(1''-pyridinium)-dodecanoyl]-4,5-dihydrosphingosine bromide...

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PMID: 17283068
DOI: 10.1074/jbc.m700647200

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