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Article

Role of Intracellular Lipid Logistics in the Preferential Usage of Very Long Chain-Ceramides in Glucosylceramide.

International journal of molecular sciences - 21 Oct 2016

Yamaji Toshiyuki, Horie Aya, Tachida Yuriko, Sakuma Chisato, Suzuki Yusuke, Kushi Yasunori, Hanada Kentaro

Abstract excerpt

Ceramide is a common precursor of sphingomyelin (SM) and glycosphingolipids (GSLs) in mammalian cells. Ceramide synthase 2 (CERS2), one of the six ceramide synthase isoforms, is responsible for the synthesis of very long chain fatty acid (C20-26 fatty acids) (VLC)-containing ceramides (VLC-Cer). It is known that the proportion of VLC species in GSLs is higher than that in SM. To address the mechanism of the...

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Identifiers

PMID: 27775668
DOI: 10.3390/ijms17101761
PMCID: PMC5085785

Genes

CERS2
UGCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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