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Article

Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs.

PloS one - 1 Jan 2014

Yamaji Toshiyuki, Hanada Kentaro

Abstract excerpt

Sphingolipids are essential components in eukaryotes and have various cellular functions. Recent developments in genome-editing technologies have facilitated gene disruption in various organisms and cell lines. We here show the disruption of various sphingolipid metabolic genes in human cervical carcinoma HeLa cells by using transcription activator-like effector nucleases (TALENs). A TALEN pair targeting the...

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PMID: 24498430
DOI: 10.1371/journal.pone.0088124
PMCID: PMC3912166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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