Article
Carbohydrate-dependent signaling from the phosphatidylglucoside-based microdomain induces granulocytic differentiation of HL60 cells.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003
Nagatsuka Yasuko, Hara-Yokoyama Miki, Kasama Takeshi, Takekoshi Masataka, Maeda Fumiko, Ihara Seiji, Fujiwara Shigeyoshi, Ohshima Eriko, Ishii Kumiko, Kobayashi Toshihide, Shimizu Kazufumi, Hirabayashi Yoshio
Abstract excerpt
Glycosphingolipids form glycosphingolipid signaling microdomains. Here, we report an unrecognized type of phosphatidylglucoside (PhGlc)-based lipid microdomain in HL60 cells. Treatment of cells with rGL-7, which preferentially reacts with PhGlc, induced differentiation of HL60 cells. This was manifested by the appearance of nitroblue tetrazolium-positive cells together with CD38 expression and c-Myc...
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