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Article

Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.

International journal of oncology - 1 Sept 1999

Lucci A, Giuliano A E, Han T Y, Dinur T, Liu Y Y, Senchenkov A, Cabot M C

Abstract excerpt

Previously we demonstrated that multidrug-resistant (MDR) cancer cells have elevated levels of a glycosylated form of ceramide, glucosylceramide. Here we compared ceramide metabolism and ceramide toxicity in MCF-7 and in adriamycin-resistant (MCF-7-AdrR) human breast cancer cells. MCF-7-AdrR cells were resistant to C6-ceramide (1-10 microM); however, in MCF-7 cells treated with C6-ceramide, viability dropped...

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Identifiers

PMID: 10427136
DOI: 10.3892/ijo.15.3.535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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