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Article

Hereditary spastic paraplegia SPG4: what is known and not known about the disease.

Brain : a journal of neurology - 1 Sept 2015

Solowska Joanna M, Baas Peter W

Abstract excerpt

Mutations in more than 70 distinct loci and more than 50 mutated gene products have been identified in patients with hereditary spastic paraplegias, a diverse group of neurological disorders characterized predominantly, but not exclusively, by progressive lower limb spasticity and weakness resulting from distal degeneration of corticospinal tract axons. Mutations in the SPAST (previously known as SPG4) gene that...

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Share to Adenosine Triphosphatases
Share to Axonal Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to SPAST gene

Share to Hereditary Neurological Disorders

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Share to Spastic Paraplegia, Hereditary

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Source

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Identifiers

PMID: 26094131
DOI: 10.1093/brain/awv178
PMCID: PMC4643622

Genes

SPAST
REEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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