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Article

Genetic background dependent modifiers of craniosynostosis severity.

Journal of structural biology - 1 Dec 2020

Dudakovic Amel, Nam Hwa Kyung, Wijnen Andre J van, Hatch Nan E

Abstract excerpt

Craniosynostosis severity varies in patients with identical genetic mutations. To understand causes of this phenotypic variation, we backcrossed the FGFR2+/C342Y mouse model of Crouzon syndrome onto congenic C57BL/6 and BALB/c backgrounds. Coronal suture fusion was observed in C57BL/6 (88% incidence, p < .001 between genotypes) but not in BALB/c FGFR2+/C342Y mutant mice at 3 weeks after birth, establishing that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 2

Source

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Identifiers

PMID: 32976998
DOI: 10.1016/j.jsb.2020.107629
PMCID: PMC7885185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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