Article

Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2 <sup>C342Y/+</sup> mouse models of Crouzon syndrome

2019-01-21

Abstract excerpt

Craniosynostosis is the premature fusion of cranial bones. The goal of this study was to determine if delivery of recombinant tissue nonspecific alkaline phosphatase (TNAP) could prevent or diminish the severity of craniosynostosis in a C57BL/6 FGFR2 C342Y/+ model of neonatal onset craniosynostosis or a BALB/c FGFR2 C342Y/+ model of postnatal onset craniosynostosis. Mice were injected with a lentivirus encoding...

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Literature Corpus work: 73851645-0e0e-598d-a3c0-584fc5eb2c4b
DOI: 10.1101/526400

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