Article
Craniofacial divergence by distinct prenatal growth patterns in Fgfr2 mutant mice.
BMC developmental biology - 28 Feb 2014
Motch Perrine Susan M, Cole Theodore M, Martínez-Abadías Neus, Aldridge Kristina, Jabs Ethylin Wang, Richtsmeier Joan T
Abstract excerpt
BACKGROUND: Differences in cranial morphology arise due to changes in fundamental cell processes like migration, proliferation, differentiation and cell death driven by genetic programs. Signaling between fibroblast growth factors (FGFs) and their receptors (FGFRs) affect these processes during head development and mutations in FGFRs result in congenital diseases including FGFR-related craniosynostosis syndromes....
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