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Article

FGFR2c-mediated ERK-MAPK activity regulates coronal suture development.

Developmental biology - 15 Jul 2016

Pfaff Miles J, Xue Ke, Li Li, Horowitz Mark C, Steinbacher Derek M, Eswarakumar Jacob V P

Abstract excerpt

Fibroblast growth factor receptor 2 (FGFR2) signaling is critical for proper craniofacial development. A gain-of-function mutation in the 2c splice variant of the receptor's gene is associated with Crouzon syndrome, which is characterized by craniosynostosis, the premature fusion of one or more of the cranial vault sutures, leading to craniofacial maldevelopment. Insight into the molecular mechanism of...

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Source

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Identifiers

PMID: 27034231
DOI: 10.1016/j.ydbio.2016.03.026
PMCID: PMC5580088

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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