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Article

New CRISPR/Cas9-based Fgfr2C361Y/+ mouse model of Crouzon syndrome exhibits skull and behavioral abnormalities.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2024

Yue Ying Ying, Lai Chen-Zhi, Guo Xiao-Shuang, Yang Chang-Sheng, Wang Yu, Song Guo-Dong, Jin Xiao-Lei

Abstract excerpt

Crouzon syndrome (CS), a syndromic craniosynostosis, is a craniofacial developmental deformity caused by mutations in fibroblast growth factor receptor 2 (FGFR2). Previous CS mouse models constructed using traditional gene editing techniques faced issues such as low targeting efficiency, extended lineage cycles, and inconsistent and unstable phenotypes. In this study, a CRISPR/Cas9-mediated strategy was employed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39158595
DOI: 10.1007/s00109-024-02476-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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