Article

Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse

2026-03-04

Abstract excerpt

The mammalian skull roof is comprised of calvarial bones, connected through fibrous sutures, that protect the brain and allow for growth. Premature suture closure, or craniosynostosis (CS), impedes expansion, impacting 1 in every 2500 newborns. Despite its genetic heterogeneity, with nearly 80 associated genes, CS manifests as a common phenotype, hinting at a convergent etiological mechanism. Recently, we describe...

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Literature Corpus work: a6bf9eee-498f-5563-8584-b37eb35ed1d5
DOI: 10.64898/2026.03.04.709647

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