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AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants

3 Mar 2021

Abstract excerpt

BACKGROUND: Changes in androgen dynamics within adipose tissue have been proposed as modulators of body fat accumulation. In this context, AKR1C2 likely plays a significant role by inactivating 5α-dihydrotestosterone. AIM: To characterize AKR1C2 expression patterns across adipose depots and cell populations and to provide insight into the link with body fat distribution and genetic regulation. METHODS: We used...

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PMID: 33675863
DOI: 10.1016/j.mce.2021.111220

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