Article
The tumour suppressor CDKN2A/p16INK4a regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue.
Diabetes & vascular disease research - 1 Nov 2017
Wouters Kristiaan, Deleye Yann, Hannou Sarah A, Vanhoutte Jonathan, Maréchal Xavier, Coisne Augustin, Tagzirt Madjid, Derudas Bruno, Bouchaert Emmanuel, Duhem Christian, Vallez Emmanuelle, Schalkwijk Casper G, Pattou François, Montaigne David, Staels Bart, Paumelle Réjane
Abstract excerpt
The genomic CDKN2A/B locus, encoding p16INK4a among others, is linked to an increased risk for cardiovascular disease and type 2 diabetes. Obesity is a risk factor for both cardiovascular disease and type 2 diabetes. p16INK4a is a cell cycle regulator and tumour suppressor. Whether it plays a role in adipose tissue formation is unknown. p16INK4a knock-down in 3T3/L1 preadipocytes or p16INK4a deficiency in mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.