Article
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
Development (Cambridge, England) - 1 Jun 1999
Clark T G, Conway S J, Scott I C, Labosky P A, Winnier G, Bundy J, Hogan B L, Greenspan D S
Abstract excerpt
Mammalian Tolloid-like 1 (mTLL-1) is an astacin-like metalloprotease, highly similar in domain structure to the morphogenetically important proteases bone morphogenetic protein-1 (BMP-1) and Drosophila Tolloid. To investigate possible roles for mTLL-1 in mammalian development, we have used gene targeting in ES cells to produce mice with a disrupted allele for the corresponding gene, Tll1. Homozygous mutants were...
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