Article

Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

2026-02-28

Abstract excerpt

Atrial cardiomyopathy is characterized by altered atrial structures and the genetic basis underlying the disorders remains inadequately explored. TIE1 variants or loss of function mutations were reported in a subset of lymphedema patients, and it is unknown whether the patients have also cardiac defects in addition to the lymphatic abnormality. We show in this study that endothelial Tie1 and Tek are highly expre...

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Literature Corpus work: 82cea786-a34d-52d4-8765-ae280585a1bd
DOI: 10.64898/2026.02.26.708190

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