Article
Heterogeneity of telomerase reverse transcriptase mutation and expression, telomerase activity and telomere length across human cancer cell lines cultured in vitro.
Experimental cell research - 1 Nov 2020
Dratwa Marta, Wysoczanska Barbara, Turlej Eliza, Anisiewicz Artur, Maciejewska Magdalena, Wietrzyk Joanna, Bogunia-Kubik Katarzyna
Abstract excerpt
Promoter region of the telomerase reverse transcriptase gene (TERTp) constitutes a regulatory element capable to affect TERT expression (TE), telomerase activity (TA) and telomere length (TL). TERTp mutation status, TL, TA and TE were assessed in 27 in vitro cultured human cell lines, including 11 solid tumour, 13 haematological and 3 normal cell lines. C228T and C250T TERTp mutations were detected in 5 solid...
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