Article
Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2020
Pirker Christine, Bilecz Agnes, Grusch Michael, Mohr Thomas, Heidenreich Barbara, Laszlo Viktoria, Stockhammer Paul, Lötsch-Gojo Daniela, Gojo Johannes, Gabler Lisa, Spiegl-Kreinecker Sabine, Dome Balazs, Steindl Ariane, Klikovits Thomas, Hoda Mir Alireza, Jakopovic Marko, Samarzija Miroslav, Mohorcic Katja, Kern Izidor, Kiesel Barbara, Brcic Luka, Oberndorfer Felicitas, Müllauer Leonhard, Klepetko Walter, Schmidt Wolfgang M, Kumar Rajiv, Hegedus Balazs, Berger Walter
Abstract excerpt
PURPOSE: Human malignant pleural mesothelioma (MPM) is characterized by dismal prognosis. Consequently, dissection of molecular mechanisms driving malignancy is of key importance. Here we investigate whether activating mutations in the telomerase reverse transcriptase (TERT) gene promoter are present in MPM and associated with disease progression, cell immortalization, and genomic alteration patterns....
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