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Article

Lipid Composition Drives Mutant Huntingtin Dimerization and Membrane Association: Insights from Computational Simulations.

Molecules (Basel, Switzerland) - 5 Jun 2026

Nicoara Catalin, Criscuolo Emanuele, De Cristofaro Angela, Fezza Filomena, Maccarrone Mauro

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of the CAG trinucleotide in the exon 1 of the huntingtin gmodellerene. This abnormal expansion produces a mutant huntingtin (mHTT) protein with extended polyglutamine (polyQ) tracts. Although the molecular mechanisms underlying HD onset and progression remain poorly understood, aberrant folding, aggregation, and membrane...

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Identifiers

PMID: 42280266
DOI: 10.3390/molecules31111965
PMCID: PMC13257622

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Lipid Composition Drives Mutant Huntingtin Dimerization and Membrane Association: Insights from Computational Simulations.PMID 42280266Read ↗

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