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Article

Increased RyR2 open probability induces neuronal hyperactivity and memory loss with or without Alzheimer's disease-causing gene mutations.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2022

Yao Jinjing, Liu Yajing, Sun Bo, Zhan Xiaoqin, Estillore John Paul, Turner Ray W, Chen S R Wayne

Abstract excerpt

INTRODUCTION: Neuronal hyperactivity is an early neuronal defect commonly observed in familial and sporadic Alzheimer's disease (AD), but the underlying mechanisms are unclear. METHODS: We employed a ryanodine receptor 2 (RyR2) mutant mouse model harboring the R4496C+/- mutation that markedly increases the channel's open probability (Po) to determine the impact of increased RyR2 activity in neuronal function...

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PMID: 34985200
DOI: 10.1002/alz.12543

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