Article

Epstein-Barr virus promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

2022-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Infection with the human-tropic Epstein-Barr virus (EBV) is a strong risk factor for multiple sclerosis (MS), though the underlying mechanisms remain unclear. To investigate the immunomodulatory effects of latent EBV infection, we induced experimental autoimmune encephalomyelitis (EAE) in immunocompromised mice humanized with peripheral blood mononuclear cells (PBMCs) from individuals with or wi...

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Literature Corpus work: 866709b1-074e-522f-b126-a6a118168b44
DOI: 10.1101/2022.02.23.481716

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