Article
Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis.
PloS one - 1 Jan 2016
Tschochner Monika, Leary Shay, Cooper Don, Strautins Kaija, Chopra Abha, Clark Hayley, Choo Linda, Dunn David, James Ian, Carroll William M, Kermode Allan G, Nolan David
Abstract excerpt
BACKGROUND: Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS-associated myelin antigens in MS patients. HLA-DRB1*15-restricted antigen presentation also appears to determine susceptibility given its role as a dominant risk allele....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.