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Article

Human Physiology of Genetic Defects Causing Beta-cell Dysfunction.

Journal of molecular biology - 6 Mar 2020

Kettunen Jarno L T, Tuomi Tiinamaija

Abstract excerpt

The last decade has revealed hundreds of genetic variants associated with type 2 diabetes, many especially with insulin secretion. However, the evidence for their single or combined effect on beta-cell function relies mostly on genetic association of the variants or genetic risk scores with simple traits, and few have been functionally fully characterized even in cell or animal models. Translating the measured...

Topics

Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Humans
Insulin
Insulin Resistance
Insulin Secretion
Insulin-Secreting Cells
Physiology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31953147
DOI: 10.1016/j.jmb.2019.12.038

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