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Article

Genome-wide association study and polygenic score assessment of insulin resistance.

Frontiers in endocrinology - 1 Jan 2024

Aliyu Usama, Umlai Umm-Kulthum Ismail, Toor Salman M, Elashi Asma A, Al-Sarraj Yasser A, Abou Samra Abdul Badi, Suhre Karsten, Albagha Omar M E

Abstract excerpt

Insulin resistance (IR) and beta cell dysfunction are the major drivers of type 2 diabetes (T2D). Genome-Wide Association Studies (GWAS) on IR have been predominantly conducted in European populations, while Middle Eastern populations remain largely underrepresented. We conducted a GWAS on the indices of IR (HOMA2-IR) and beta cell function (HOMA2-%B) in 6,217 non-diabetic individuals from the Qatar Biobank (QBB;...

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Identifiers

PMID: 38938516
DOI: 10.3389/fendo.2024.1384103
PMCID: PMC11208314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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