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Article

Culture and multiomic analysis of lung cancer patient-derived pleural effusions revealed distinct druggable molecular types.

Scientific reports - 15 Apr 2022

Seo Ha-Young, Kim Soon-Chan, Roh Woo-Lee, Shin Young-Kyoung, Kim Soyeon, Kim Dong-Wan, Kim Tae Min, Ku Ja-Lok

Abstract excerpt

Malignant pleural effusion (MPE) is an independent determinant of poor prognostic factor of non-small cell lung cancer (NSCLC). The course of anchorage independent growth within the pleural cavity likely reforms the innate molecular characteristics of malignant cells, which largely accounts for resistance to chemotherapy and poor prognosis after the surgical resection. Nevertheless, the genetic and transcriptomic...

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Identifiers

PMID: 35428753
DOI: 10.1038/s41598-022-10318-5
PMCID: PMC9012760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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